Unlock easy and continuous monitoring of your microfluidic device to control conditions and assess cellular metabolic activities with PyroScience sensors. We offer a range of customized solutions for optical oxygen, pH and temperature measurements in miniaturized systems and especially for microfluidic applications in addition to our standard products (e.g. OXNANO and OXSP5).

These custom sensor solutions are distinguished by their compact size and low dead volume and include:

• Microfluidic flow-through cells
• Sensor Spots optimized for miniaturized/microfluidic systems
• O2 Minispot Integration Service 

 

Microfluidic flow-through cells

Connect our microfluidic flow-through cells to your system to monitor the conditions within the fluid. The microfluidic flow-through cells are available for pH (item no. PHFTC-PK7-MF) or oxygen (item no OXFTC-MF) measurement. They have either an integrated pH sensor or oxygen sensor and an integrated temperature sensor, allowing precision pH (oxygen) measurements in aqueous liquids pumped through the cell. They are especially suited for low flow-rates (1μL/min – 1500 μL/min pH; 20µl/min -1500µl/min O2). The integrated temperature sensor allows accurate in-situ temperature compensation of the pH (oxygen) measurement. The flow-through cells can be connected directly to the FireSting® read-out meter with two optical fibers SPFIB-BARE(-CL2). Standard connectors allow easy connection to microfluidic systems.

O2 and pH Sensor Spots optimized for miniaturized/microfluidic systems

Insert our sensor spots into your miniaturized system and get control on conditions inside. Measurement of in-situ oxygen, pH and T measurements in miniaturized devices can be realized (in small order quantity) with customizable oxygen and pH sensor spots and sensor foils optimized for miniaturized/microfluidic systems (item no. OXSPOT-MF-CV or OXFOIL-MF-CV for O2 and PHSPOT-CV or PHFOIL-CV for pH). Those custom versions are available in different shapes and sizes, you can simply choose the format that fits best your application. Simply integrate and read-out contactless through transparent windows in combination with the FirePlate-O2 for parallelized measurements, the FireSting meters or the OEM PICO product family for custom integration into your electronics.

Oxygen Minispot Integration Service

Scale up while getting even smaller with our Oxygen Sensor Integration Service! This service allows for individual positioning of O2 Sensor Minispots in your miniaturized devices according to your application needs, especially for medium to high order quantities. Via this service, O2 Sensor Minispots with a spot diameter of 0.5 or 1 mm can be integrated directly inside miniaturized structures made from different materials, for example glass, COP/COC, PET, PMMA, PC and PS. The O2 Sensor Minispots are biocompatible and compatible to individual chip processing steps (bonding, cleaning and sterilization methods)– learn more and request our catalogue! Read-out of the integrated Minispots in miniaturized devices can be performed through transparent chip materials in combination with the FirePlate-O2 for parallelized measurements, the FireSting meters or the OEM PICO product family for custom integration into your electronics.

Plug & Play Microfluidic Chips with integrated PyroScience Sensor Technology

Do you require ready-to-use microfluidic biochips equipped with state-of-the-art oxygen minisensors (REDFLASH technology) to develop intricate in vitro models for biomedical research? Then explore fully integrated organ-on-chip technology from Dynamic42, featuring non-invasive oxygen measurement using PyroScience sensor technology. The DynamicOrgan® O2-Sensor Kit enables real-time, contact-free, and non-invasive detection of oxygen consumption within organ models such as lung, gut or liver-on-chip.

 

Our products for microfluidic applications have been already applied successfully by leading research facilities in the MPS field and allow applications such as:

• Continuous monitoring of pH and dissolved oxygen levels in 3D (microfluidic) cell culture systems
• Hypoxia, cancer and stem cell research
• Indirect monitoring of cell viability in toxicological screening studies
• Metabolic evaluation of complex 3D tissue-engineered constructs
• Assessment of cellular respiration and glycolysis
• Monitoring of extracellular acidification rate (ECAR) of the cell culture medium
• Understanding available oxygen levels and gradients inside organ-on-a-chip systems and spheroids
• Evaluation of chip material gas permeability for material selection during microfluidic chip fabrication
• Your application?

For more applications see our application website.
The PyroScience sensor support teams have a deep background in microfluidics, chemistry, physics, life sciences and electronical engineering for in-depth support for your application.
Find the best sensor solution for your microfluidic with the help of our experts, simply contact: info@pyroscience.com.